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consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calciumphosphateparathyroid hormone (PTH) monitoringrather than positioning vitamin D as disease-modifying therapy for unselected CKD
92 , 5397 (1990) A
It analyzes pathway-level variants (GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313)) that relate to the biology involved, offering context for a conversation with your provider rather than a prediction
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